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KIT and PDGFRA Muta...
KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial
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- Joensuu, Heikki (author)
- Helsinki University Central Hospital
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- Wardelmann, Eva (author)
- University Hospital Münster
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- Eriksson, Mikael (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Reichardt, Annette (author)
- HELIOS Klinikum Berlin-Buch
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- Hall, Kirsten Sundby (author)
- Norwegian Radium Hospital
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- Schütte, Jochen (author)
- Alfried Krupp Krankenhaus
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- Cameron, Silke (author)
- University of Göttingen
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- Hohenberger, Peter (author)
- Heidelberg University
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- Sihto, Harri (author)
- University of Helsinki
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- Jost, Philipp J. (author)
- Klinikum rechts der Isar
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- Lindner, Lars H. (author)
- University Hospital Munich
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- Bauer, Sebastian (author)
- University Hospital Essen
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- Nilsson, Bengt (author)
- Sahlgrenska University Hospital
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- Kallio, Raija (author)
- Oulu University Hospital
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Pesonen, Tommi (author)
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- Reichardt, Peter (author)
- HELIOS Klinikum Berlin-Buch
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(creator_code:org_t)
- 2023
- 2023
- English 7 s.
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In: Clinical Cancer Research. - 1078-0432. ; 29:17, s. 3313-3319
- Related links:
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Abstract
Subject headings
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- Purpose: Limited data are available about the influence of KIT and PDGFRA mutations on overall survival (OS) of patients with gastrointestinal stromal tumor (GIST) treated with adjuvant imatinib. Patients and Methods: The Scandinavian Sarcoma Group XVIII/AIO multicenter trial accrued 400 patients with a high risk for GIST recurrence after macroscopically complete surgery between February 4, 2004, and September 29, 2008. The patients received adjuvant imatinib 400 mg/day for either 1 year or 3 years based on random allocation. We analyzed using conventional sequencing KIT and PDGFRA mutations centrally from 341 (85%) patients who had localized, centrally confirmed GIST, and correlated the results with recurrence-free survival (RFS) and OS in exploratory analyses. Results: During a median follow-up time of 10 years, 164 RFS events and 76 deaths occurred. Most patients were re-treated with imatinib when GIST recurred. Patients with KIT exon 11 deletion or indel mutation treated with 3 years of adjuvant imatinib survived longer than patients treated for 1 year [10-year OS 86% versus 64%, respectively; HR, 0.34; 95% confidence interval (CI), 0.15-0.72; P 0.007], and also had longer RFS (10-year RFS 47% versus 29%; HR, 0.48; 95% CI, 0.31-0.74; P < 0.001). Patients with KIT exon 9 mutation had unfavorable OS regardless of the duration of adjuvant imatinib. Conclusions: Compared with 1 year of imatinib, 3 years of adjuvant imatinib led to 66% reduction in the estimated risk of death and a high 10-year OS rate in the subset of patients with a KIT exon 11 deletion/indel mutation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Joensuu, Heikki
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Wardelmann, Eva
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Eriksson, Mikael
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Reichardt, Annet ...
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Hall, Kirsten Su ...
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Schütte, Jochen
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Cameron, Silke
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Hohenberger, Pet ...
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Sihto, Harri
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Jost, Philipp J.
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Lindner, Lars H.
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Bauer, Sebastian
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Nilsson, Bengt
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Kallio, Raija
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Pesonen, Tommi
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Reichardt, Peter
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Clinical Cancer ...
- By the university
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Lund University